A few years ago

nmaes64906

December 7, Huaihua, China's first AIDS care center - Hongjiang district care center. Laohong care center (a pseudonym) in the baby to play. Yang poetry photo
Timothy Ray Brown (Timothy & nbsp; Ray Brown) must be the most compelling in 2010 patients.
 
Everything about him was very mysterious, very few people know his hair color, possessor of any pets at home, or like what a movie star. Nevertheless, the media around the world are rushing to report this to live in Berlin, Germany,doudoune moncler pas cher, 42-year-old white man. He had been a full 10 years of AIDS entangled. December 8, a seven-member team from the German three University School of Medicine study published online staff paper said, "Our results demonstrate that the patient has been cured of AIDS" on the famous scientific journal "Blood."
 
Since HIV was discovered in 1981, in this "century killer" to kill as many as 60 million people in the list, Brown may be the first and currently the only one cure people. The German patient's recovery is considered "shocking breakthrough."
 
The treatment of leukemia cure AIDS
 
Miracles happen in a red brick building, which is located in the German capital of Charlotte's Hospital, it is Europe's largest university hospital.
 
Brown is old patient of this hospital. Since 10 years ago was diagnosed with AIDS, he has been receiving medical treatment here. Virus did not defeat this middle-aged man's body, but has been quietly lurking in his body.
 
AIDS Research Center at Tsinghua University, Professor Zhang Linqi opinion, this is a terrible place for HIV. If the cell as a wallet, this virus is like a robber. This appears under the microscope like a "little thorn ball" of the virus, it will break the "treasury" door "security code", rushed into the interior of the cell. Then, it will be integrated into their mark innermost cell chromosome, it becomes part of the cell.
 
Today, the danger that people bring to this robbery is no longer strange, it will attack the body's immune system is the most important T4 lymphoid tissue. Once the immunohistochemical crash resistance man becomes low, most likely due to infection died.
 
Looters might lurk in a patient over 10 years. Thus, when people drug "Police" to send the patient when infected,piumini moncler, they are often difficult to track down these hidden bad guys quietly.
 
Brown has been living under the shadow of these robbers. Meanwhile, another terrible disease and quietly wrap him. A few years ago, the hapless man diagnosed with leukemia. Under the two "incurable disease" in the attack, it seems, he almost lost the possibility to survive.
 
However, Charlotte hospital clinicians director Eckhard Thiel (Eckhard & nbsp; T & nbsp; hiel) did not give up, the main hematology and oncology doctors decided to conduct a bold attempt. In the mid-90s of the last century, American scientists have found that some people will not be born with HIV infection. Steele and his colleagues began to think, if you find a "born from HIV-infected patients" with Brown matching bone marrow donors, the "treatment of leukemia with a bone marrow transplant, the patient is not HIV virus We will follow disappear along with it? "
 
In fact, in ordinary cells,http://www.k-macs.ne.jp/~anb/cgi-bin/nicky.cgi,piumini moncler, "treasury", most of the set up two "security code", a process called CD4, The other is called CCR5. But for HIV, it is very easy to crack two passwords, so-called security measures useless.
 
But those born to HIV "immune" lucky cell, due to mutations, CCR5 gene coding region amino acid No. 185 after a 32 bp deletion occurred. This is called defective gene CCR5 △ 32 is equivalent to treasury encryption,http://bowling.s52.xrea.com/i/epad/epad.cgi?res=8297, robbers no matter what tricks resorted to, they can not sneak into the vault.
 
Brown is very fortunate for Brown in 60 bone marrow transplant donors, the research team found people who have CCR5 △ 32 gene for him. In February 2007, when Brown undergo the transplant, the donor's bone marrow begin functioning in his body, began to produce new blood cells.
 
As doctors had envisioned it, the newly generated cells have defective CCR5 △ 32 gene. After 3 years of follow-up investigation, the doctors were sure a miracle happened, "HIV in the patient's body completely disappeared."
 
In this we even dare to mention aloud "cure" in the field of the word, this is definitely enlightening discovery
 
Just over a year ago, as the case wrote papers published in prestigious world medical community, "New England Journal of Medicine." At that time, the research team from Germany is cautioned that "by bone marrow transplantation long-term control of HIV." Zhang Linqi remember, this case make the whole field of science "very shocked."
 
Prior to that paper was published, this terrible virus has been called "post-century history of the plague." HIV is known as the world's "number one infectious disease killer", there are 200 million people have died each year.
 
World Health Organization also their official website wrote that if adhere to treatment, "people living with HIV can be kept in good condition, to maintain the ability to work to extend the life time,http://mizu-masa.sakura.ne.jp/yokkaichi/movie/sunbbs2/sunbbs.cgi?mode=form&no=1997&page=1,hogan outlet online, even in low-income countries, people living with HIV can do." However, WHO is also categorically said: "HIV can not be cured."
 
Therefore, when Brown could not find the body of HIV whereabouts, Reuters reported wrote in this "we could not even mention aloud 'cure' word in the field, this is definitely enlightening discovery" .
 
Although this is a kind of "incurable" disease, but research it has not run aground. Currently, antiviral treatment can prolong life of 30 years to 50 years, compared with the life expectancy of a complete cure is only 10 years earlier.
 
90s of last century,woolrich outlet italia, Chinese scientist David Ho made the famous "cocktail therapy", ie to use several drugs, each drug against HIV reproductive cycle of different segments, so as to inhibit or kill HIV purpose.
 
In November,http://sea-arts.com, an article published by the University of California, San Francisco research team in the "New England Journal of Medicine," the paper said, antiretroviral drugs may reduce the risk of infection and the spread of AIDS rate to some extent, "it first once again it proved that regular use of drugs can reduce HIV part in gay and bisexual men at high risk of propagation velocity. "
 
Ho has served as an assistant in the United States Zhang Linqi found that, although the drug can inhibit new cells are infected, but have been infected cells but can survive for long periods in the body. The virus lurks quietly, causing the drug even simply can not find. This became the "biggest obstacle to cure AIDS."
 
He put HIV as a "microscopic world of Superman", although only a few of 100 nanometers in diameter, but it is a "formidable opponent."
 
A few years ago, this has been beaten for 19 years and AIDS dealings "returnees" Professor decided to begin to develop an AIDS vaccine. Now, in laboratory animal experiments, the vaccine has produced "a very good observation."
 
In July, the US National Institute of Allergy and Infectious Diseases specialist research published in the "Science" journal, said the discovery of two can "bind" and to combat more than 90 %% variant strains of HIV antibodies.
 
However, this does not mean that the vaccine will soon be put into production. Zhang Linqi said: "Although the direction is clear, but how long the road,http://caorenren.com/forum.php?mod=viewthread&tid=5008355, who knows."
 
When Brown was cured after the news,http://store.shopping.yahoo.co.jp/dearbabys/mud-173775.html, those who believe that "it is impossible to cure a disease," the scientists were very excited. This proves conjecture before the medical profession, "if the use of genetic means to knock CCR532 base cell surface, so the body of HIV-infected persons can be completely removed."
 
Some European and American scientists have ready encourage CCR5 △ 32 type crowd to donate bone marrow, and find a suitable matching in HIV-infected individuals worldwide. They excitedly told desperate patient, "Do not worry, AIDS can be cured."
 
Lucky is not easy to replicate Brown
 
However,http://www.ggsdwp.com/forum.php?mod=viewthread&tid=5332, you want to copy Brown's luck is not an easy task. In Zhang Linqi opinion, the German patients were healing process, just like "lightning struck several times in a row a small probability event." An HIV-infected patients with leukemia, one pair of HIV "immunity" of bone marrow matching, one can afford to pay huge medical expenses wallet, these elements are indispensable.
 
At least, a Chinese patient difficult to accomplish this, because few people have the yellow gene CCR5 △ 32 people. In the 100 Europeans, and only one person has such a strong ability to protect the mutant gene.
 
American Medical Association AIDS virus Zag former president believes that "if this method becomes standard therapy, there is a big risk."
 
Currently, stem cell or bone marrow transplantation commonly used in cancer treatment, but no one knows healthy people need to take much if you accept the risk of this operation. It involves the use of powerful drugs and radiation to destroy the immune system, the body of the original, and then enter the donor's bone marrow, in order to re-create a new immune system, and lead to complications of the therapy is likely to increase mortality.
 
"This method is not practical, but it is possible to kill people." Dr. Gallo human viruses, University of Maryland, said. 26 years ago, it was the scientist and his work partners discovered the HIV virus. "I do not want to pour cold water on this interesting thing, though, you know, this is, at best, just a funny thing. And, until the dead, carried out a detailed examination, in order to fully determine the virus completely disappeared."
 
For Zhang Linqi, the "science of unpredictability too, when things start to look only fun, but in the end it is likely to bring milestones."
 
His former colleagues Paxton is a good example. The virologist is also a homosexual. The mid-90s of the last century, out of curiosity, his own blood around some gay friends were detected. The result was a surprise, some people are easily infected with HIV, while the other part will not be infected.
 
Scientists have found a CCR5 △ 32 on an experimental basis on Paxton. And it is more than ten years ago that the experiment was carried out of curiosity, Brown saved the patient's life in Germany.
 
"Scientific development can not step away from a cure for AIDS may have a long way, but at least now taken the first step." Zhang Linqi said. The AIDS virus for long been engaged in research for a professor, this peculiar German patient at least proved one thing, if we can knock down CCR5 32 bases in the body, there is the possibility to cure AIDS.
 
"On the basis of scientific research, plan never catch up with rapid change, no one can say for sure, what is at what moment, in which the laboratory,http://www.alzbrain.org/prevention.cgi, this study will be successful." He said earnestly.